Your body already makes it.

Sermorelin is a synthetic 29-amino-acid peptide that acts as an analog of growth hormone-releasing hormone (GHRH). It stimulates the pituitary gland to produce and release more of your body’s own growth hormone. Unlike direct HGH injections, sermorelin works through your natural feedback mechanisms rather than introducing external growth hormone.

Sermorelin was previously FDA-approved under the brand name Geref® but was voluntarily discontinued by its manufacturer in the mid-2000s — not due to safety or efficacy concerns. Compounded sermorelin is not FDA-approved as a finished drug product. The FDA does not evaluate compounded medications for safety, effectiveness, or quality. It is legally prepared by a licensed compounding pharmacy and prescribed by a licensed provider after clinical evaluation.

HGH therapy introduces synthetic growth hormone directly into your body, bypassing the pituitary gland entirely. Sermorelin takes a different approach — it signals your pituitary gland to produce more of its own growth hormone, keeping your body’s natural regulatory mechanisms intact. They are fundamentally different therapies with different mechanisms, risk profiles, and regulatory considerations. Your provider can help determine which approach, if any, may be appropriate for you.

Sermorelin is administered as a daily subcutaneous injection, typically at bedtime. Bedtime dosing is standard because growth hormone is naturally released in pulses during deep sleep. You inject it under the skin of your abdomen, thigh, or upper arm using the insulin syringes provided. Your provider will set your starting dose and may adjust it based on lab work and your clinical response.

The most common side effect is mild injection site irritation — redness, swelling, or pain — reported in approximately 1 in 6 patients during clinical trials. Less common side effects include headache, facial flushing, dizziness, nausea, and temporary changes in taste. Serious side effects are rare but can include allergic reactions. Your provider will monitor your response and adjust your protocol as needed.

Sermorelin works gradually over weeks and months. Some patients report improvements in sleep quality and energy within the first few weeks. Changes in body composition, recovery, and other areas may take 3–6 months of consistent use. Individual results vary significantly based on age, health status, lifestyle, and adherence to treatment. Your provider will use lab testing (including IGF-1 levels) to monitor your progress. Results are not guaranteed.

Sermorelin may be considered for adults experiencing symptoms associated with age-related growth hormone decline — such as low energy, poor sleep quality, slow recovery from exercise, and changes in body composition. A licensed provider will evaluate your health history, current medications, and lab results to determine if sermorelin is clinically appropriate. It is generally not recommended for individuals with active cancer, certain uncontrolled endocrine disorders, or women who are pregnant or breastfeeding.

Yes. No contracts and no cancellation fees. Cancel anytime through your patient portal or by messaging our support team. Your current month’s shipment will always be sent before any cancellation takes effect.